Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines.

ID: ALA1833873

Journal: Bioorg Med Chem Lett

Title: Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines.

Authors: Kojima N, Suga Y, Hayashi H, Yamori T, Yoshimitsu T, Tanaka T.

Abstract: The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated γ-lactone fragment. It was revealed that the number of fluorine atoms on the γ-lactone moiety affects the growth inhibitory activities against human cancer cell lines.

CiteXplore: 21875800

DOI: 10.1016/j.bmcl.2011.08.011

Patent ID: ┄