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ID: ALA1833892
Journal: Bioorg Med Chem Lett
Title: Synthesis and acrosin inhibitory activities of substituted ethyl 5-(4-aminophenyl)-1H-pyrazole-3-carboxylate derivatives.
Authors: Qi J, Zhu J, Liu X, Ding L, Zheng C, Han G, Lv J, Zhou Y.
Abstract: A series of novel ethyl 5-(4-aminophenyl)-1H-pyrazole-3-carboxylate derivatives were designed and synthesized and their in vitro acrosin inhibitory activities were evaluated. Most of the compounds exhibited acrosin inhibitory activities. Among them, three compounds (5l, 5n, and 5v) were more potent than that of the control TLCK. These provide a new structural type for the development of novel contraceptive acrosin inhibitory agents.
CiteXplore: 21880490