Hydrazidomycins, cytotoxic alkylhydrazides from Streptomycesatratus.

ID: ALA1833908

Journal: Bioorg Med Chem Lett

Title: Hydrazidomycins, cytotoxic alkylhydrazides from Streptomycesatratus.

Authors: Ueberschaar N, Ndejouong Ble S, Ding L, Maier A, Fiebig HH, Hertweck C.

Abstract: Three unusual alkyhydrazide natural products, named hydrazidomycin A (1), B (2) and C (3), were isolated from the chloroform extract of a Streptomycesatratus culture, and their structures were elucidated by MS and NMR techniques. Hydrazidomycins A-C exhibited moderate to strong cytotoxic activities in a panel of 42 cell lines, with hydrazidomycin A being the most potent compound (mean IC(50)=0.37 μM).

CiteXplore: 21868221

DOI: 10.1016/j.bmcl.2011.07.108

Patent ID: ┄