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ID: ALA1909538
Journal: Bioorg Med Chem Lett
Title: Iodine-catalyzed conjugate addition of indoles onto en-1,4-dione: a novel synthesis of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-ones as antibacterial and antifungal agents.
Authors: Reddy BV, Rajeswari N, Sarangapani M, Roopa Reddy G, Madan Ch, Pranay Kumar K, Srinivasa Rao M.
Abstract: Indole and its derivatives undergo smooth conjugate addition onto en-1,4-dione derived from isatin and acetophenone, in the presence of a catalytic amount of molecular iodine in acetonitrile under mild conditions to afford a novel class of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-one derivatives in good yields with high degree of 1,4-selectivity. Some of these compounds are found to exhibit modest antibacterial and antifungal properties.
CiteXplore: 21924612