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ID: ALA1909542
Journal: Bioorg Med Chem Lett
Title: Synthesis and acrosin inhibitory activity of substituted 4-amino-N-(diaminomethylene) benzenesulfonamide derivatives.
Authors: Ding L, Zhu J, Zheng C, Sheng C, Qi J, Liu X, Han G, Zhao J, Lv J, Zhou Y.
Abstract: A series of new substituted 4-amino-N-(diaminomethylene) benzenesulfonamides were synthesized and their in vitro acrosin inhibitory activities were evaluated. Most of the compounds showed potent acrosin inhibitory activities with compounds 4o and 4p being significantly more potent than the control compound N-alpha-tosyl-L-lysyl-chloromethyl-ketone (TLCK). The compounds provide a new scaffold for the development of acrosin inhibitory agents.
CiteXplore: 21983437