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ID: ALA1909550

Journal: Bioorg Med Chem Lett

Title: Designing 2-aminoimidazole alkaloids analogs with anti-biofilm activities: structure-activities relationships of polysubstituted triazoles.

Authors: Linares D, Bottzeck O, Pereira O, Praud-Tabariès A, Blache Y.

Abstract: In order to discover novel probes that may help in the investigation and the control of bacterial biofilms, we have designed a library of triazole-based analogs of 2-aminoimidazole marine alkaloids: naamine A and isonaamine A. Twenty-two compounds were screened for their biofilm inhibitory activity against two strains of Gram-negative bacteria. Four compounds were shown to act as non-toxic inhibitors of biofilm development without effect on bacterial growth even at high concentrations (100 μM).

CiteXplore: 21982498

DOI: 10.1016/j.bmcl.2011.09.050