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ID: ALA1909601
Journal: Bioorg Med Chem Lett
Title: Synthesis and structure-activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors.
Authors: Gewald R, Rueger C, Grunwald C, Egerland U, Hoefgen N.
Abstract: The synthesis and SAR studies of a series of structurally novel inhibitors of PDE7 are discussed. The best compounds from the series display low nanomolar inhibitory activity and are selective versus other PDE isoenzymes.
CiteXplore: 21983442