Document Report Card

ID: ALA1914363

Journal: J Nat Prod

Title: Identification of a naturally occurring quinazolin-4(3H)-one firefly luciferase inhibitor.

Authors: Somanadhan B, Leong C, Whitton SR, Ng S, Buss AD, Butler MS.

Abstract: A prefractionated Streptomyces-derived extract was initially identified as being active using a luciferase-based AMP-activated protein kinase (AMPK) assay. Bioassay-guided fractionation led to the isolation of the new compound quinazolin-4(3H)-one (1) as the active component. However, 1 was shown to have potent firefly luciferase inhibitory activity with no effect on AMPK. This is the first report of a natural luciferase inhibitor.

CiteXplore: 21639131

DOI: 10.1021/np1006179