Document Report Card
Basic Information
ID: ALA1921751
Journal: Bioorg Med Chem Lett
Title: Discovery of small molecules that enhance astrocyte differentiation in rat fetal neural stem cells.
Authors: Chang DJ, Jeong MY, Song J, Jin CY, Suh YG, Kim HJ, Min KH.
Abstract: 1,3,4-Oxadiazole derivatives were found to enhance astrocyte differentiation in rat fetal neural stem cells (NSCs). Differentiation activity was assessed by immunocytochemistry and analysis of mRNA expression of astrocyte markers, GFAP and S100. Compounds 7 and 8 showed approximately a two-fold increase in astrocyte differentiation without engagement of neuronal differentiation and detectable cytotoxicity.
CiteXplore: 22001087