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ID: ALA1921790
Journal: Bioorg Med Chem Lett
Title: Synthesis and antimicrobial activity of brominated resorcinol dimers.
Authors: Bouthenet E, Oh KB, Park S, Nagi NK, Lee HS, Matthews SE.
Abstract: Dibrominated resorcinol dimers were synthesized by reaction of 4-bromoresorcinol with aldehydes under reflux in ethanol in the presence of HCl. Subsequent dehalogenation yielded the corresponding monobrominated compounds and a fully dehalogenated dimer. Of the dimers, 6,6'-((4-hydroxyphenyl)methylene)bis(4-bromobenzene-1,3-diol) (4) displayed potent antibacterial activity and inhibitory activity against isocitrate lyase Candida albicans.
CiteXplore: 22001028