Biaryl analogues of teriflunomide as potent DHODH inhibitors.

ID: ALA1926525

Journal: Bioorg Med Chem Lett

Title: Biaryl analogues of teriflunomide as potent DHODH inhibitors.

Authors: Erra M, Moreno I, Sanahuja J, Andrés M, Reinoso RF, Lozoya E, Pizcueta P, Godessart N, Castro-Palomino JC.

Abstract: The structure-activity relationships of a novel series of biaryl dihydroorotate dehydrogenase (DHODH) inhibitors related to teriflunomide are disclosed. These biaryl derivatives were the result of structure-based design and proved to be potent DHODH inhibitors which in addition showed good antiproliferative activities on peripheral blood mononuclear cells and good efficacies in vivo in the rat adjuvant-induced-arthritis model.

CiteXplore: 22078215

DOI: 10.1016/j.bmcl.2011.10.052

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