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ID: ALA1926636

Journal: Eur J Med Chem

Title: Isoxazoles incorporated N-substituted decahydroquinolines: a precursor to the next generation antimicrobial drug.

Authors: Babu M, Pitchumani K, Ramesh P.

Abstract: We report here a simple entry into N-substituted decahydroisoxazoloquinoline system with substituents at position 3 and 4 from the readily available substrates for the first time. The synthesized isoxazoloquinolines were evaluated against six bacterial and four fungal strains. The results suggest that the decahydroisoxazolo[4,3-c]quinoline scaffold has the potential to be developed into therapeutically useful antimicrobial agents.

CiteXplore: 22133458

DOI: 10.1016/j.ejmech.2011.10.045