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ID: ALA1932964
Journal: Bioorg Med Chem Lett
Title: Lead optimisation of pyrazoles as novel FPR1 antagonists.
Authors: Morley AD, King S, Roberts B, Lever S, Teobald B, Fisher A, Cook T, Parker B, Wenlock M, Phillips C, Grime K.
Abstract: Optimisation of a series of pyrazole inhibitors of the human FPR1 receptor has been achieved. The use of an in vitro media loss assay was utilised to identify sub-series with more robust DMPK profiles. These were subsequently improved to generate analogues with attractive overall profiles.
CiteXplore: 22094028