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ID: ALA1932969
Journal: Bioorg Med Chem Lett
Title: Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs.
Authors: Kumar A, Shah BA, Singh S, Hamid A, Singh SK, Sethi VK, Saxena AK, Singh J, Taneja SC.
Abstract: Boswellic acid acylates including their epimers were synthesized and screened against a panel of human cancer cell lines. They exhibited a range of cytotoxicity against various human cancer cell lines thereby leading to the development of a possible SAR. One of the identified lead compounds was found to be an inhibitor of the NF-κB and STAT proteins, warranting further investigations to be developed into a potential anticancer lead.
CiteXplore: 22123322