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ID: ALA1932998
Journal: Bioorg Med Chem
Title: Design, synthesis and evaluation of polar head group containing 2-keto-oxazole inhibitors of FAAH.
Authors: Rusch M, Zahov S, Vetter IR, Lehr M, Hedberg C.
Abstract: 2-α-Keto oxazoles containing polar head groups in their C5-side chains were designed as fatty acid amide hydrolase (FAAH) inhibitors. Variation in the spacer length resulted in submicromolar α-keto-oxazole FAAH inhibitor (IC(50)=436 nM) presenting electrostatic stabilizing interactions between its polar head group contained in the C5-side chain and the hydrophilic pocket of the enzyme.
CiteXplore: 22196515