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ID: ALA1938331
Journal: Bioorg Med Chem Lett
Title: Discovery of novel and potent CRTH2 antagonists.
Authors: Ito S, Terasaka T, Zenkoh T, Matsuda H, Hayashida H, Nagata H, Imamura Y, Kobayashi M, Takeuchi M, Ohta M.
Abstract: High throughput screening of our chemical library for CRTH2 antagonists provided a lead compound 1a. Initial optimization of the lead led to the discovery of a novel, potent and orally bioavailable CRTH2 antagonist 17.
CiteXplore: 22178554