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ID: ALA1938343
Journal: Bioorg Med Chem Lett
Title: Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2.
Authors: De Savi C, Morley AD, Nash I, Karoutchi G, Page K, Ting A, Gerhardt S.
Abstract: Directed screening has identified a novel series of non-zinc binding MMP13 inhibitors that possess good levels of activity whilst demonstrating excellent selectivity over related MMPs. A lead optimisation campaign has delivered compounds with enhanced MMP13 potency, good selectivity and acceptable bioavailability profiles leading to a predicted twice-a-day dosing regimen in man.
CiteXplore: 22153941