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ID: ALA1949551
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors.
Authors: Song B, Xiao T, Qi X, Li LN, Qin K, Nian S, Hu GX, Yu Y, Liang G, Ye F.
Abstract: Monoamine oxidase-B (MAO-B) inhibitor has been used as neuroprotectants to treat the motor deficits of Parkinson's disease (PD). We designed and synthesized a class of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors. The compounds have various inhibitory effects, with compound 6a having a K(i) value of 0.26 μM. Their promising activity in vitro suggests potential use in the treatment of PD.
CiteXplore: 22257893