Synthesis and interaction with midkine of biotinylated chondroitin sulfate tetrasaccharides.
Basic Information
ID: ALA1949552
Journal: Bioorg Med Chem Lett
Title: Synthesis and interaction with midkine of biotinylated chondroitin sulfate tetrasaccharides.
Authors: Tamura J, Tsutsumishita-Nakai N, Nakao Y, Kawano M, Kato S, Takeda N, Nadanaka S, Kitagawa H.
Abstract: Regiospecifically sulfated chondroitin sulfate repeating tetrasaccharides, CS-OO, GlcAβ-GalNAcβ-GlcAβ-GalNAcβ;CS-EE, GlcAβ-GalNAc(4S6S)β-GlcAβ-GalNAc(4S6S)β; and CS-AA, GlcAβ-GalNAc(4S)β-GlcAβ-GalNAc(4S)β, having biotin linked with a hydrophilic linker at the reducing terminal were synthesized effectively by a coupling of the corresponding disaccharide units and regioselective sulfation. CS-EE showed greater affinity for midkine than CS-AA and CS-OO.
CiteXplore: 22237251
DOI: 10.1016/j.bmcl.2011.12.054
Patent ID: ┄