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ID: ALA1949559

Journal: Bioorg Med Chem Lett

Title: Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine.

Authors: Wu Z, Yang C, Xiong Y, Feng Z, Lombardo M, Verras A, Chabin RM, Xu S, Tong X, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Chen Q, Sinharoy R, Hale JJ, Tata JR, Pinto S, Shen DM, Colletti SL.

Abstract: Efforts to modify the central proline portion of lead compound 4 lead to the discovery of novel prolylcarboxypeptidase (PrCP) inhibitors. Especially, replacement with alanine afforded compound 19 displaying more potent human and mouse PrCP inhibitory activity than 4 and an overall comparable profile.

CiteXplore: 22248857

DOI: 10.1016/j.bmcl.2011.12.064