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ID: ALA1955773
Journal: Bioorg Med Chem Lett
Title: Hit to lead SAR study on benzoxazole derivatives for an NPY Y5 antagonist.
Authors: Omori N, Kouyama N, Yukimasa A, Watanabe K, Yokota Y, Tanioka H, Nambu H, Yukioka H, Sato N, Tanaka Y, Sekiguchi K, Okuno T.
Abstract: We report a hit to lead study on a novel benzoxazole NPY Y5 antagonist. Starting from HTS hit 1, structure-activity relationships were developed. Compound 12 showed reduction of food intake and a tendency to suppress body weight gain over the 21-day experimental period.
CiteXplore: 22300657