Design and synthesis of novel 7-aminoquinazoline derivatives: antitumor and anticonvulsant activities.
Basic Information
ID: ALA1955778
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of novel 7-aminoquinazoline derivatives: antitumor and anticonvulsant activities.
Authors: El-Azab AS, Eltahir KE.
Abstract: A novel series of 7-substituted-4(3H)-quinazolinone were designed, synthesized and evaluated for their antitumor and anticonvulsant activity. Compound 7 revealed broad-spectrum antitumor effectiveness toward numerous cell lines that belong to different tumor subpanels, whereas compounds 9 and 18 possess selective activity toward leukemia cell lines. Additionally, compounds 3, 15, 16, 18, 19 and 20 showed advanced anticonvulsant activity as well as lower neurotoxicity than reference drugs. The achieved results proved that the distinctive compounds could be valuable as a model for future devise, acclimatization and investigation to construct more active analogues.
CiteXplore: 22326394
DOI: 10.1016/j.bmcl.2012.01.071
Patent ID: ┄