Substituted azaquinazolinones as modulators of GHSr-1a for the treatment of type II diabetes and obesity.

ID: ALA1955830

Journal: Bioorg Med Chem Lett

Title: Substituted azaquinazolinones as modulators of GHSr-1a for the treatment of type II diabetes and obesity.

Authors: Hanrahan P, Bell J, Bottomley G, Bradley S, Clarke P, Curtis E, Davis S, Dawson G, Horswill J, Keily J, Moore G, Rasamison C, Bloxham J.

Abstract: Substituted azaquinazolinones were identified as antagonists of the GHSr-1A receptor for the treatment of type II diabetes and obesity. Optimisation for potency and LogD lead to the identification of orally bioavailable, potent antagonists with improved selectivity over hERG.

CiteXplore: 22342626

DOI: 10.1016/j.bmcl.2012.01.078

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