Document Report Card
Basic Information
ID: ALA2010714
Journal: Bioorg Med Chem Lett
Title: Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
Authors: Brinkevich SD, Boreko EI, Savinova OV, Pavlova NI, Shadyro OI.
Abstract: The ability of ascorbic acid and a number of its derivatives to suppress replication of Herpes simplex virus type I was investigated in human rhabdomyosarcoma cell line. In parallel, interaction of the test compounds with carbon- and oxygen-centered radicals formed on radiolysis of hydroxyl-containing organic compounds was studied using the steady state radiolysis method. It has been shown that 2-O-glycoside of ascorbic acid, displaying marked antiviral properties against Herpes simplex virus type I, is also capable of inhibiting fragmentation and recombination reactions of α-hydroxyl-containing carbon-centered radicals while not affecting processes involving oxygen-centered radicals.
CiteXplore: 22390834