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ID: ALA2016442
Journal: Bioorg Med Chem Lett
Title: Structure-activity studies of some berberine analogs as inhibitors of Toxoplasma gondii.
Authors: Krivogorsky B, Pernat JA, Douglas KA, Czerniecki NJ, Grundt P.
Abstract: The shortfalls of the current treatment options against infections with the parasite Toxoplasma gondii (T. gondii) necessitates the development of non-toxic and well-tolerated alternatives. To address this problem a structurally diverse panel of berberine alkaloids was synthesized and evaluated for in vitro inhibition of T. gondii tachyzoites. Inhibitory doses (ID(50)) of less than 50 nM and therapeutic indices (TI) up to 4000 were observed.
CiteXplore: 22425568