Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity.
Basic Information
ID: ALA2016534
Journal: ACS Med Chem Lett
Title: Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity.
Authors: Liu KK, Zhu J, Smith GL, Yin MJ, Bailey S, Chen JH, Hu Q, Huang Q, Li C, Li QJ, Marx MA, Paderes G, Richardson PF, Sach NW, Walls M, Wells PA, Baxi S, Zou A.
Abstract: Highly selective PI3K inhibitors with subnanomolar PI3Kα potency and greater than 7000-fold selectivity against mTOR kinase were discovered through structure-based drug design (SBDD). These tetra-substituted thiophenes were also demonstrated to have good in vitro cellular potency and good in vivo oral antitumor activity in a mouse PI3K driven NCI-H1975 xenograft tumor model. Compounds with the desired human PK predictions and good in vitro ADMET properties were also identified. In this communication, we describe the rationale behind the installation of a critical triazole moiety to maintain the intricate H-bonding network within the PI3K receptor leading to both better potency and selectivity. Furthermore, optimization of the C-4 phenyl group was exploited to maximize the compounds mTOR selectivity.
CiteXplore: 24900269
DOI: 10.1021/ml200126j
Patent ID: ┄