New triazole derivatives as antifungal agents: synthesis via click reaction, in vitro evaluation and molecular docking studies.
Basic Information
ID: ALA2016536
Journal: Bioorg Med Chem Lett
Title: New triazole derivatives as antifungal agents: synthesis via click reaction, in vitro evaluation and molecular docking studies.
Authors: Zou Y, Zhao Q, Liao J, Hu H, Yu S, Chai X, Xu M, Wu Q.
Abstract: A series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols (5a-5y) which are analogues of fluconazole, have been designed and synthesized via Cu(I)-catalyzed azide-alkyne cycloaddition on the basis of computational docking experiments to the active site of the cytochrome P450 14α-demethylase (CYP51). The in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi. Compound 5l showed the best antifungal activities.
CiteXplore: 22437114
DOI: 10.1016/j.bmcl.2012.02.042
Patent ID: ┄