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ID: ALA2021816
Journal: Bioorg Med Chem Lett
Title: Synthesis and acrosin inhibitory activity of methyl 5-substituted-1H-benzo[d]imidazol-2-yl carbamate derivatives.
Authors: Liu X, Chen Q, Zhu J, Fan Y, Ding L, Zhao J, Han G, Tian W, Qi J, Zhou Y, Lv J.
Abstract: A series of novel methyl 5-substituted 1H-benzo[d]imidazol-2-ylcarbamates were designed, synthesized, and their acrosin inhibitory activities evaluated in vitro. The results of acrosin inhibitory activity showed that all title compounds were more potent than the control TLCK. Compound 4w displayed the most potent acrosin inhibitory activity among all the compounds, with an IC(50) of 6.3×10(-5)M. The studies provide a new structural class for the development of novel acrosin inhibitory agents.
CiteXplore: 22507960