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ID: ALA2021915

Journal: Eur J Med Chem

Title: Synthesis, characterization and biological activity of hydroxyl-bisphosphonic analogs of bile acids.

Authors: Bortolini O, Fantin G, Fogagnolo M, Rossetti S, Maiuolo L, Di Pompo G, Avnet S, Granchi D.

Abstract: Bisphosphonates (BPs) are now the most widely used drugs for diseases associated with increased bone resorption, such as osteoporosis, and tumor bone diseases. A significant drawback of the BPs is their poor oral absorption that is enhanced by the presence of bile acid substituents in the bisphosphonate framework, with no toxic effects. A straightforward synthesis of bile acid-containing hydroxy-bisphosphonates and a full characterization of these pharmaceutically important molecules, including an evaluation of affinity and the mechanism of binding to hydroxyapatite, is presented. The biological activity of bile acid-containing bisphosphonate salts was determined using the neutral-red assay on the L929 cell line and primary cultures of osteoclasts. The bioactivity of the new compounds was found superior than bisphosphonates of established activity.

CiteXplore: 22483634

DOI: 10.1016/j.ejmech.2012.03.020