Document Report Card
Basic Information
ID: ALA2029304
Journal: Bioorg Med Chem Lett
Title: Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists.
Authors: Noel R, Song X, Shin Y, Banerjee S, Kojetin D, Lin L, Ruiz CH, Cameron MD, Burris TP, Kamenecka TM.
Abstract: The design and synthesis of a novel series of Rev-erbα agonists is described. The development and optimization of the tetrahydroisoquinoline series was carried out from an earlier acyclic series of Rev-erbα agonists. Through the optimization of the scaffold 1, several potent compounds with good in vivo profiles were discovered.
CiteXplore: 22560469