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ID: ALA2029315
Journal: Bioorg Med Chem Lett
Title: Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.
Authors: Keck GE, Poudel YB, Rudra A, Stephens JC, Kedei N, Lewin NE, Blumberg PM.
Abstract: The role of the C(8) gem-dimethyl group in the A-ring of bryostatin 1 has been examined through chemical synthesis and biological evaluation of a new analogue. Assays for biological function using U937, K562, and MV4-11 cells as well as the profiles for downregulation of PKC isozymes revealed that the presence of this group is not a critical determinant for the unique pattern of biological activity of bryostatin.
CiteXplore: 22579485