Document Report Card

ID: ALA2034926

Journal: J Med Chem

Title: Design, synthesis, and biological action of 20R-hydroxyvitamin D3.

Authors: Lu Y, Chen J, Janjetovic Z, Michaels P, Tang EK, Wang J, Tuckey RC, Slominski AT, Li W, Miller DD.

Abstract: The non-naturally occurring 20R epimer of 20-hydroxyvitamin D3 is synthesized based on chemical design and hypothesis. The 20R isomer is separated by semipreparative HPLC, and its structure is characterized. A comparison of 20R isomer to its 20S counterpart in biological evaluation demonstrates that they have different behaviors in antiproliferative and metabolic studies.

CiteXplore: 22404326

DOI: 10.1021/jm201478e