Document Report Card

ID: ALA2040741

Journal: J Nat Prod

Title: Hyaladione, an S-methyl cyclohexadiene-dione from Hyalangium minutum.

Authors: Okanya PW, Mohr KI, Gerth K, Steinmetz H, Huch V, Jansen R, Müller R.

Abstract: A bioassay-guided fractionation of the crude methanol extract of the myxobacterium Hyalangium minutum, strain NOCB-2(T) (DSM 14724(T)), led to the isolation of hyaladione (1), a novel S-methyl cyclohexadiene-dione. The structure of 1 was established by HRESIMS, NMR, and IR spectroscopy as well as X-ray crystallography. Compound 1 was active against growing mammalian cell lines, with IC(50) values ranging from 1.23 to 3.93 μM, in addition to a broad spectrum of antibacterial and antifungal activities, including inhibition of pathogenic methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa with an MIC of 0.83 and 8.5 μg mL(-1), respectively.

CiteXplore: 22497473

DOI: 10.1021/np200776v