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ID: ALA2046370
Journal: Bioorg Med Chem
Title: Beta-carboline alkaloids derived from the ascidian Synoicum sp.
Authors: Won TH, Jeon JE, Lee SH, Rho BJ, Oh KB, Shin J.
Abstract: Six β-carboline alkaloids (1-6) of the eudistomin Y class were isolated from the Korean ascidian Synoicum sp. These compounds were chemically converted to a known compound, eudistomin Y(1) (7) and six new derivatives, designated eudistomins Y(8)-Y(13) (8-13). Several of these natural and synthetic compounds exhibited moderate to significant antimicrobial activity, weak cytotoxic activity, and inhibitory activities toward sortase A, isocitrate lyase, and Na(+)/K(+)-ATPase. Structure-activity relationships were also deduced.
CiteXplore: 22652254