Antibacterial anthraquinone derivatives from a sea anemone-derived fungus Nigrospora sp.
Basic Information
ID: ALA2046419
Journal: J Nat Prod
Title: Antibacterial anthraquinone derivatives from a sea anemone-derived fungus Nigrospora sp.
Authors: Yang KL, Wei MY, Shao CL, Fu XM, Guo ZY, Xu RF, Zheng CJ, She ZG, Lin YC, Wang CY.
Abstract: Chemical investigation of a marine-derived fungus Nigrospora sp., isolated from an unidentified sea anemone, yielded two new hydroanthraquinone analogues, 4a-epi-9α-methoxydihydrodeoxybostrycin (1) and 10-deoxybostrycin (2), together with seven known anthraquinone derivatives (3-9). The structures of the two new compounds were established through extensive NMR spectroscopy as well as a single-crystal X-ray diffraction analysis using Cu Kα radiation. The antibacterial activities of compounds 1-9 and 10 acetyl derivatives (6a, 7a, 8a-8g, 9a) were evaluated in vitro. Compound 6a, the acetylated derivative of 6, exhibited promising activity against Bacillus cereus with an MIC value of 48.8 nM, which was stronger than that of the positive control ciprofloxacin (MIC = 1250 nM). Analysis of the antibacterial screening data for the metabolites and their acetyl derivatives revealed the key structural features required for this activity.
CiteXplore: 22545792
DOI: 10.1021/np300103w
Patent ID: ┄