The optimization of pyridazinone series of glucan synthase inhibitors.

ID: ALA2057100

Journal: Bioorg Med Chem Lett

Title: The optimization of pyridazinone series of glucan synthase inhibitors.

Authors: Kuang R, Wu H, Ting PC, Aslanian RG, Cao J, Kim DW, Lee JF, Schwerdt J, Zhou G, Herr RJ, Zych AJ, Yang J, Lam SQ, Jenkins DM, Sakwa SA, Wainhaus S, Black TA, Cacciapuoti A, McNicholas PM, Xu Y, Walker SS.

Abstract: A detailed structure-activity relationship study of a novel series of pyridazine-based small molecule glucan synthase inhibitors is described. The optimization of the PK profile of this series led to the discovery of compound 11g, which demonstrated in vivo potency ip in a lethal fungal infection model.

CiteXplore: 22818082

DOI: 10.1016/j.bmcl.2012.06.091

Patent ID: ┄