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ID: ALA2062407
Journal: Bioorg Med Chem
Title: Synthesis of N²-modified 7-methylguanosine 5'-monophosphates as nematode translation inhibitors.
Authors: Piecyk K, Davis RE, Jankowska-Anyszka M.
Abstract: Preparative scale synthesis of 14 new N(2)-modified mononucleotide 5' mRNA cap analogues was achieved. The key step involved use of an S(N)Ar reaction with protected 2-fluoro inosine and various primary and secondary amines. The derivatives were tested in a parasitic nematode, Ascaris suum, cell-free system as translation inhibitors. The most effective compound with IC(50) ∼0.9μM was a N(2)-p-metoxybenzyl-7-methylguanosine-5'-monophosphate 35.
CiteXplore: 22748379