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ID: ALA2069168
Journal: Bioorg Med Chem
Title: Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile.
Authors: Toba T, Murata K, Futamura J, Nakanishi K, Takahashi B, Takemoto N, Tomino M, Nakatsuka T, Imajo S, Goto M, Yamamura T, Miyake S, Annoura H.
Abstract: A series of truncated analogs of α-galactosylceramide with altered ceramide moiety was prepared, and evaluated for Th2-biased response in the context of IL-4/IFN-γ ratio. Phytosphingosine-modified analogs including cyclic, aromatic and ethereal compounds as well as the C-glycoside analog of OCH (2) with their cytokine inducing profile are disclosed.
CiteXplore: 22480852