Document Report Card

Basic Information

ID: ALA2069183

Journal: Bioorg Med Chem Lett

Title: Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C).

Authors: Leurs U, Clausen RP, Kristensen JL, Lohse B.

Abstract: The human histone demethylases of the KDM4 (JMJD2) family have been associated to diseases such as prostate and breast cancer, as well as X-linked mental retardation. Therefore, these enzymes are considered oncogenes and their selective inhibition might be a possible therapeutic approach to treat cancer. Here we describe a heterocyclic ring system library screened against the histone demethylase KDM4C (JMJD2C) in the search for novel inhibitory scaffolds. A 4-hydroxypyrazole scaffold was identified as an inhibitor of KDM4C; this scaffold could be employed in the further development of novel therapeutics, as well as for the elucidation of the biological roles of KDM4C on epigenetic regulation.

CiteXplore: 22917519

DOI: 10.1016/j.bmcl.2012.07.091