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ID: ALA2069240
Journal: Bioorg Med Chem Lett
Title: Design, solvent free synthesis, and antimicrobial evaluation of 1,4 dihydropyridines.
Authors: Murthy YL, Rajack A, Taraka Ramji M, Jeson babu J, Praveen Ch, Aruna Lakshmi K.
Abstract: Here in, we report the usage of cellulose sulfuric acid as a heterogeneous eco friendly catalyst for the synthesis of 1,4 dihydropyridines under solvent free conditions via Hantzsch three component reaction of an aldehyde, ethyl acetoacetate and ammonium acetate at 100 °C for 2-5 h. In silico studies were performed on twenty two possible 1,4 dihydropyridines (DHPs) analogues against K(+) channel receptor (KcsA). In order to validate in silico studies, thirteen compounds were synthesized and evaluated as antibacterials against twenty seven ESBL isolates of Klebsiella pneumoniae and Escherichia coli.
CiteXplore: 22901391