Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein--potential novel positron emitting ...
Basic Information
ID: ALA2069301
Journal: Bioorg Med Chem Lett
Title: Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein--potential novel positron emitting tomography imaging agents.
Authors: Wadsworth H, Jones PA, Chau WF, Durrant C, Morisson-Iveson V, Passmore J, O'Shea D, Wynn D, Khan I, Black A, Avory M, Trigg W.
Abstract: A series of novel ligands based on the diaryl anilide (DAA) class of translocator protein (TSPO) ligands was synthesised and evaluated as potential positron emitting tomography (PET) ligands for imaging TPSO in vivo. Fluorine-18 labelling of the molecules was achieved using direct radiolabelling or synthon based labelling approaches. Several of the ligands prepared have promising profiles as potential TSPO PET imaging ligands and will be evaluated further as potential clinical imaging agents.
CiteXplore: 22902658
DOI: 10.1016/j.bmcl.2012.07.093
Patent ID: ┄