Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.
Basic Information
ID: ALA2074262
Journal: Biochem Biophys Res Commun
Title: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.
Authors: Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A.
Abstract: We identified three novel transporters structurally belonging to the organic anion transporting polypeptide (OATP) family in humans. Since previously known rat oatp1 to 3 do not necessarily correspond to the human OATPs in terms of either tissue distribution or function, here we designate the newly identified human OATPs as OATP-B, -D and -E, and we rename the previously known human OATP as OATP-A. OATP-C proved to be identical with the recently reported LST1/OATP-2. Expression profiles of the five OATPs and the prostaglandin transporter PGT (a member of OATP family) in human tissues showed that OATP-C is exclusively localized in liver, OATP-A and PGT are expressed in restricted ranges of tissues, and OATP-B, -D and -E show broad expression profiles. OATP-B, -C, -D and -E exhibited transport activity for [(3)H]estrone-3-sulfate as a common substrate. OATP-C has a high transport activity with broad substrate specificity.
CiteXplore: 10873595
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