A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells.
Basic Information
ID: ALA2086235
Journal: Bioorg Med Chem
Title: A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells.
Authors: Onen-Bayram FE, Durmaz I, Scherman D, Herscovici J, Cetin-Atalay R.
Abstract: The forward chemogenomics strategy allowed us to identify a potent cytotoxic thiazolidine compound as an apoptosis-inducing agent. Chemical structures were designed around a thiazolidine ring, a structure already noted for its anticancer properties. Initially, we evaluated these novel compounds on liver, breast, colon and endometrial cancer cell lines. The compound 3 (ALC67) showed the strongest cytotoxic activity (IC(50) ∼5 μM). Cell cycle analysis with ALC67 on liver cells revealed SubG1/G1 arrest bearing apoptosis. Furthermore we demonstrated that cytotoxicity of this compound was due to the activation of caspase-9 involved apoptotic pathway, which is death receptor independent.
CiteXplore: 22867707
DOI: 10.1016/j.bmc.2012.07.016
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