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ID: ALA2086282
Journal: Bioorg Med Chem Lett
Title: 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases.
Authors: Chen P, Horton LB, Mikulski RL, Deng L, Sundriyal S, Palzkill T, Song Y.
Abstract: Bacterial resistance to β-lactam antibiotics caused by class B metallo-β-lactamases (MBL), especially for certain hospital-acquired, Gram-negative pathogens, poses a significant threat to public health. We report several 2-substituted 4,5-dihydrothiazole-4-carboxylic acids to be novel MBL inhibitors. Structure activity relationship (SAR) and molecular modeling studies were performed and implications for further inhibitor design are discussed.
CiteXplore: 22921080