Document Report Card
Basic Information
ID: ALA2086326
Journal: Bioorg Med Chem Lett
Title: Biological activity evaluation and structure-activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer.
Authors: Li W, Li N, Tang Y, Li B, Liu L, Zhang X, Fu H, Duan JA.
Abstract: The anticancer activities of alkyl esters and NO-donors of ferulic acid (FA) and caffeic acid (CA) were assessed by a high-throughout screening (HTS) method, and the structure-activity relationships were described. CA alkyl esters had better anticancer activities than FA alkyl esters with the same alkyl substituent. Mono-nitrates and phenylfuroxan nitrates were more potent than the dual nitrates. Phenylsulfonylfuroxan nitrates of FA, especially compounds 8b-8d, exhibited more potent activities in anticancer.
CiteXplore: 22954735