Document Report Card

ID: ALA2146468

Journal: J Nat Prod

Title: Thrombin inhibitors from the freshwater cyanobacterium Anabaena compacta.

Authors: Anas AR, Kisugi T, Umezawa T, Matsuda F, Campitelli MR, Quinn RJ, Okino T.

Abstract: Bioassay-guided investigation of the cyanobacterium Anabaena compacta extracts afforded spumigin J (1) and the known thrombin inhibitor spumigin A (2). The absolute configuration of 1 was analyzed by advanced Marfey's methodology. Compounds 1 and 2 inhibited thrombin with EC(50) values of 4.9 and 2.1 μM, and 0.7 and 0.2 μM in the cathepsin B inhibitory assay, respectively. The MM-GBSA methodology predicted spumigin A with 2S-4-methylproline as the better thrombin inhibitor.

CiteXplore: 22950366

DOI: 10.1021/np300282a