Document Report Card

ID: ALA2146475

Journal: J Med Chem

Title: A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity.

Authors: Xia Y, Wang M, Demaria O, Tang J, Rocchi P, Qu F, Iovanna JL, Alexopoulou L, Peng L.

Abstract: A novel bitriazolyl acyclonucleoside was discovered to exhibit powerful antiproliferative effects on different cancer cell lines through caspase-dependent apoptosis and at the same time stimulate the immune response in dendritic cells via Toll-like receptor 7 (TLR7) signaling. This promising compound with dual anticancer and immunomodulatory activity may represent a new generation of highly efficacious drug candidates for use in cancer therapy.

CiteXplore: 22578090

DOI: 10.1021/jm300534u