Document Report Card

ID: ALA2163211

Journal: J Nat Prod

Title: Antiviral chromones from the stem of Cassia siamea.

Authors: Hu QF, Zhou B, Gao XM, Yang LY, Shu LD, Shen Y, Li GP, Che CT, Yang GY.

Abstract: Seven new chromones, siamchromones A-G (1-7), and 12 known chromones (8-19) were isolated from the stems of Cassia siamea. Compounds 1-19 were evaluated for their antitobacco mosaic virus (anti-TMV) and anti-HIV-1 activities. Compound 6 showed antitobacco mosaic virus (anti-TMV) activity with an inhibition rate of 35.3% and IC50 value of 31.2 μM, which is higher than that of the positive control, ningnamycin. Compounds 1, 10, 13, and 16 showed anti-TMV activities with inhibition rates above 10%. Compounds 4, 6, 13, and 19 showed anti-HIV-1 activities with therapeutic index values above 50.

CiteXplore: 23078294

DOI: 10.1021/np300395m