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ID: ALA2163336
Journal: J Nat Prod
Title: Tyrosinase inhibitors from the wood of Artocarpus heterophyllus.
Authors: Nguyen NT, Nguyen MH, Nguyen HX, Bui NK, Nguyen MT.
Abstract: From the methanolic-soluble extract of the wood of Artocarpus heterophyllus, four new flavones, artocarmins A-D (1-4), and three new chalcones, artocarmitins A-C (5-7), have been isolated together with 13 known compounds. Their structures were determined on the basis of the spectroscopic data. Compounds 1-4, 6, 7, 9-16, and 20 displayed significant tyrosinase inhibitory activity. The most active compound, morachalcone A (12) (IC50, 0.013 μM), was 3000 times more active as a tyrosinase inhibitor than a positive control, kojic acid (IC50, 44.6 μM).
CiteXplore: 23113717
DOI: 10.1021/np300576w