Document Report Card

ID: ALA2169789

Journal: J Med Chem

Title: Potent HGF/c-Met axis inhibitors from Eucalyptus globulus: the coupling of phloroglucinol and sesquiterpenoid is essential for the activity.

Authors: Yang SP, Zhang XW, Ai J, Gan LS, Xu JB, Wang Y, Su ZS, Wang L, Ding J, Geng MY, Yue JM.

Abstract: Eucalyptin A (1), together with two known compounds 2 and 3 exhibiting potent inhibition on HGF/c-Met axis, was discovered from the fruits of Eucalyptus globulus. 1 possessed an unprecedented carbon framework of phloroglucinol-coupled sesquiterpenoid, and its structure was elucidated by spectroscopic method and ECD calculation. A brief structure-activity relationship discussion indicated that the coupling of a phloroglucinol and a sesquiterpenoid is essential for the activity.

CiteXplore: 22934600

DOI: 10.1021/jm3007454